Fujimoto M, Kiyosawa T, Murata S, Matsuo K, Suzuki H, Sone H, Okuda Y, Nakayama Y, Yaoita H
Department of Plastic Surgery, University of Tsukuba, Ibaraki, Japan.
Anticancer Res. 1998 Sep-Oct;18(5B):3725-9.
Angiosarcoma(AS) is a malignant tumour of the endothelium of lymphatic or blood vessels. Vascular endothelial growth factor (VEGF), a specific mitogen of endothelial cells, is considered essential for the growth of many tumours including AS. We have recently treated several patients with AS; in two of them, using a newly developed enzyme-linked immunosorbent assay (ELISA) for VEGF, we sequentially measured serum VEGF concentrations. While serial serum VEGF levels reflected tumour burden, the various VEGF concentrations were within the normal range we reported previously. Furthermore, the VEGF concentrations were not remarkably elevated in AS tumour tissue compared with benign vascular lesions and hypervascular tumours.
血管肉瘤（AS）是一种起源于淋巴管或血管内皮的恶性肿瘤。血管内皮生长因子（VEGF）是一种内皮细胞特异性有丝分裂原，被认为对包括AS在内的许多肿瘤的生长至关重要。我们最近治疗了几名AS患者；其中两名患者，我们使用新开发的VEGF酶联免疫吸附测定（ELISA）法，连续测量血清VEGF浓度。虽然系列血清VEGF水平反映了肿瘤负荷，但各种VEGF浓度都在我们之前报告的正常范围内。此外，与良性血管病变和高血管肿瘤相比，AS肿瘤组织中的VEGF浓度并没有显著升高。
