Brazier J S, Duerden B I
PHLS Anaerobe Reference Unit, University Hospital of Wales, Heath Park, Cardiff.
Commun Dis Public Health. 1998 Dec;1(4):229-30.
The availability of surveillance data on C. difficile infection in hospitals in England and Wales is being jeopardised by the trend not to culture the organism for diagnostic purposes. NHS trust laboratories that no longer have the ability to isolate C. difficile cannot investigate putative outbreaks or monitor antimicrobial susceptibilities. These laboratories may now need to rely on their local public health laboratory for such investigations. Recent recommendations from the Department of Health(DH)/PHLS have highlighted the need for culture in outbreak investigations, for surveillance purposes, and for monitoring antimicrobial susceptibilities. It is important, therefore, that NHS diagnostic laboratories and public health laboratories, in particular, retain the ability to isolate C. difficile. A cost-effective approach is described that will facilitate surveillance by typing of strains and also enable their antimicrobial susceptibilities to be monitored.
英格兰和威尔士医院中艰难梭菌感染监测数据的可得性正受到一种趋势的威胁，即出于诊断目的而不再对该病原体进行培养。不再有能力分离艰难梭菌的国民保健服务信托实验室无法调查疑似疫情或监测抗菌药物敏感性。这些实验室现在可能需要依靠当地公共卫生实验室进行此类调查。卫生部/公共卫生实验室服务处最近的建议强调了在疫情调查、监测目的以及监测抗菌药物敏感性方面进行培养的必要性。因此，国民保健服务诊断实验室，尤其是公共卫生实验室，保留分离艰难梭菌的能力非常重要。本文描述了一种具有成本效益的方法，该方法将通过菌株分型促进监测，并能够监测其抗菌药物敏感性。
