Sen A, Mukherjea M
Department of Biochemistry, University College of Science, Calcutta.
Indian J Biochem Biophys. 1998 Aug;35(4):216-23.
Placental syncytiotrophoblast while regulating the passage of nutrients from maternal blood to the fetal circulation exposes itself to the risk of oxidative attack by the oxygen free radicals. Extent of lipid peroxidation (LPO) investigated in placental brush border membrane (BBM) and basal membrane (BM) revealed a decreasing trend with gestational progress. Steady-state fluorescence anisotropy measurement of 1,6-diphenyl-1,3,5-hexatriene (DPH)-labeled malondialdehyde treated placental membrane vesicles suggested modulation of BBM and BM fluidity by lipid peroxidation in all gestational ages. alpha-tocopherol content in both the placental membranes which increased as gestation progressed has been proposed to play a significant role in decreasing LPO of placental membranes during intrauterine development.
胎盘合体滋养层在调节营养物质从母体血液进入胎儿循环的过程中，自身面临着被氧自由基氧化攻击的风险。对胎盘刷状缘膜（BBM）和基底膜（BM）中脂质过氧化（LPO）程度的研究表明，随着孕周增加呈下降趋势。对用1,6 - 二苯基 - 1,3,5 - 己三烯（DPH）标记的丙二醛处理的胎盘膜囊泡进行稳态荧光各向异性测量表明，脂质过氧化在所有孕周都会调节BBM和BM的流动性。随着孕周增加，两种胎盘膜中的α - 生育酚含量均升高，这被认为在子宫内发育期间降低胎盘膜的LPO方面发挥重要作用。
