Grunwald T, Lehnertz K, Helmstaedter C, Kutas M, Pezer N, Kurthen M, Van Roost D, Elger C E
Department of Epileptology, Bonn University Medical Center, Germany.
Neuroreport. 1998 Oct 26;9(15):3375-8. doi: 10.1097/00001756-199810260-00007.
Surgical removal of the dominant medial temporal lobe regions runs a considerable risk of verbal memory deficits which may be compensated for postoperatively by corresponding regions in the non-dominant medial temporal lobe. We examined this possibility by recording event-related potentials (ERPs) to words from the medial temporal lobes of patients with left-sided temporal lobe epilepsy (TLE) undergoing presurgical evaluation. N400 amplitudes in the right anterior medial temporal lobe predicted the postoperative verbal recall performance of individual patients with surprising accuracy, indicating that intracranial recordings can be used to quantify the functional capacities of the right hemisphere that can compensate for the verbal memory deficits after loss of medial temporal lobe structures in the left hemisphere.
手术切除占主导地位的内侧颞叶区域存在导致言语记忆缺陷的重大风险，术后这些缺陷可能由非主导侧内侧颞叶的相应区域进行代偿。我们通过记录左侧颞叶癫痫（TLE）患者在术前评估时内侧颞叶对单词的事件相关电位（ERP）来研究这种可能性。右侧前内侧颞叶的N400波幅以惊人的准确性预测了个体患者术后的言语回忆表现，这表明颅内记录可用于量化右半球的功能能力，该能力可在左半球内侧颞叶结构丧失后代偿言语记忆缺陷。
