Hermann B P, Seidenberg M, Haltiner A, Wyler A R
EpiCare Center, Memphis, Tennessee 38103.
Cortex. 1992 Sep;28(3):423-33. doi: 10.1016/s0010-9452(13)80152-9.
We examined adequacy of language functions, their influence on verbal learning and memory performance, and the relative effects of language function and laterality of seizure focus on the memory performance of 99 left-hemisphere dominant patients with invasively verified epilepsy of left (N = 47) or right (N = 52) temporal lobe origin. Patients with left temporal lobe epilepsy (TLE) scored significantly lower than the right TLE group on several aphasia battery subtests (Visual Naming, Sentence Repetition, Token Test, Reading Comprehension, Aural Comprehension). Adequacy of language function (nominal speech) was significantly related to verbal learning and memory performance for both left and right TLE groups. Finally, comparison of the predictive significance of laterality of TLE and adequacy of language function indicated that language functions (Visual Naming and Aural Comprehension), but not laterality of TLE, were significant predictors for verbal learning and memory performance. It is concluded that: 1) adequacy of basic language functions is particularly compromised in left TLE, 2) there is a significant relationship between adequacy of language function and several aspects of verbal learning and memory ability in both left and right temporal lobe groups, and 3) clinical assessment and theoretical models of memory need to consider these relationships.
我们研究了语言功能的充分性、其对言语学习和记忆表现的影响，以及语言功能和癫痫发作灶的偏侧性对99例经侵入性验证为左侧（N = 47）或右侧（N = 52）颞叶起源的左半球优势癫痫患者记忆表现的相对影响。在多项失语症成套测验子测试（视觉命名、句子复述、代币测试、阅读理解、听觉理解）中，左侧颞叶癫痫（TLE）患者的得分显著低于右侧TLE组。对于左侧和右侧TLE组，语言功能（命名性言语）的充分性与言语学习和记忆表现显著相关。最后，对TLE偏侧性和语言功能充分性的预测意义进行比较表明，语言功能（视觉命名和听觉理解）而非TLE偏侧性是言语学习和记忆表现的显著预测因素。研究得出以下结论：1）左侧TLE患者的基本语言功能充分性尤其受损；2）在左侧和右侧颞叶组中，语言功能充分性与言语学习和记忆能力的多个方面之间存在显著关系；3）记忆的临床评估和理论模型需要考虑这些关系。
