Navarro M, Chowen J, Rocío A Carrera M, del Arco I, Villanúa M A, Martin Y, Roberts A J, Koob G F, de Fonseca F R
Instituto Universitario de Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de Madrid, Spain.
Neuroreport. 1998 Oct 26;9(15):3397-402. doi: 10.1097/00001756-199810260-00012.
Recent reports have provided evidence of a link between the endogenous brain cannabinoid system and the endogenous central opioid systems. Here we report that the selective CB1 receptor antagonist SR 141716A induced behavioral and endocrine alterations associated with opiate withdrawal in morphine-dependent animals in a dose-dependent manner and that naloxone induced an opiate withdrawal syndrome in animals made cannabinoid-dependent by repeated administration of the potent cannabinoid agonist HU-210. Additionally CB1 and mu-opioid receptor mRNAs were co-localized in brain areas relevant for opiate withdrawal such as the nucleus accumbens, septum, dorsal striatum, the central amygdaloid nucleus and the habenular complex. These results suggest that CB1 cannabinoid receptors may play a role in the neuroadaptive processes associated with opiate dependence, and they lend further support for the hypothesis of a potential role of cannabinoid receptors in the neurobiological changes that culminate in drug addiction.
最近的报告提供了内源性脑大麻素系统与内源性中枢阿片系统之间存在联系的证据。在此我们报告，选择性CB1受体拮抗剂SR 141716A以剂量依赖的方式在吗啡依赖动物中诱导出与阿片戒断相关的行为和内分泌改变，并且纳洛酮在通过反复给予强效大麻素激动剂HU - 210而产生大麻素依赖的动物中诱导出阿片戒断综合征。此外，CB1和μ - 阿片受体mRNA在与阿片戒断相关的脑区共定位，如伏隔核、隔区、背侧纹状体、中央杏仁核和缰核复合体。这些结果表明，CB1大麻素受体可能在与阿片依赖相关的神经适应性过程中起作用，并且它们进一步支持了大麻素受体在导致药物成瘾的神经生物学变化中可能发挥作用这一假说。
