Castanheira D, Marzella M, Skirvin J A
University of Pittsburgh Cancer Institute, Pennsylvania, USA.
Pharmacotherapy. 1998 Nov-Dec;18(6):1347-51.
Two patients experienced agranulocytosis associated with either procainamide or trimethoprim-sulfamethoxazole. Both were treated with filgrastim in an attempt to decrease the duration of agranulocytosis. The first patient received 12 days and the second patient 4 days of filgrastim before white blood cell counts recovered. Published reports both support and refute the efficacy of filgrastim in this setting. The agent may be beneficial in certain cases of this disorder, but further investigation is necessary to determine if it has a definitive role.
两名患者分别出现了与普鲁卡因胺或甲氧苄啶-磺胺甲恶唑相关的粒细胞缺乏症。两人均接受了非格司亭治疗，试图缩短粒细胞缺乏症的持续时间。第一名患者在白细胞计数恢复前接受了12天的非格司亭治疗，第二名患者接受了4天。已发表的报告对非格司亭在这种情况下的疗效既有支持也有反驳。该药物在这种疾病的某些病例中可能有益，但需要进一步研究以确定它是否具有明确作用。
