Wickramanayake P D, Scheid C, Josting A, Katay I, Schulz A, Diehl V
First Department of Internal Medicine, University of Cologne, Germany.
Eur J Med Res. 1995 Dec 18;1(3):153-6.
Five patients with non-cytotoxic drug-induced agranulocytosis were treated with recombinant human granulocyte-colony-stimulating factor (rh-G-CSF). The drugs involved were dipyrone, captopril, clozapine and carbimazole. Bone marrow examination revealed a depleted granulopoiesis with normal erythro- and megakaryocytopoiesis. After discontinuation of the suspected drug, rh-G-CSF was administered daily at 5 microg/kg subcutaneously. The neutrophil counts were recovered between day 6 and 12 and patients were discharged from hospital shortly afterwards. Compared to data from the literature, the neutrophil recovery appeared to be faster than expected without the use of haematopoietic growth factors. In conclusion, rh-G-CSF at a standard dose of 5 microg/kg seems to be an effective treatment for drug-induced agranulocytosis.
5例非细胞毒性药物所致粒细胞缺乏症患者接受了重组人粒细胞集落刺激因子（rh-G-CSF）治疗。涉及的药物有安乃近、卡托普利、氯氮平和甲巯咪唑。骨髓检查显示粒细胞生成减少，而红系和巨核系细胞生成正常。停用可疑药物后，每天皮下注射5μg/kg的rh-G-CSF。中性粒细胞计数在第6天至第12天恢复，患者随后不久出院。与文献数据相比，在未使用造血生长因子的情况下，中性粒细胞恢复似乎比预期更快。总之，标准剂量为5μg/kg的rh-G-CSF似乎是治疗药物性粒细胞缺乏症的有效方法。
