肉毒杆菌神经毒素A和E型中毒后人类不同的恢复时间进程。

Different time courses of recovery after poisoning with botulinum neurotoxin serotypes A and E in humans.

作者信息

Eleopra R, Tugnoli V, Rossetto O, De Grandis D, Montecucco C

机构信息

Divisione Neurologica, Arcispedale S. Anna, Ferrara, Italy.

出版信息

Neurosci Lett. 1998 Nov 13;256(3):135-8. doi: 10.1016/s0304-3940(98)00775-7.

DOI:10.1016/s0304-3940(98)00775-7

PMID:9855358

Abstract

Botulinum toxin serotypes A and E (BoNT/A and /E) cleave the carboxy-terminus of synaptosomal associated protein-25 (SNAP-25) removing nine and 26 residues, respectively. To investigate the effect of these lesions of the same target molecule, 11 volunteers were injected with 3 IU of BoNT/A in the extensor digitorum brevis (EDB) muscle of one foot and with 3 IU of BoNT/E in the contralateral one. In addition, seven volunteers were similarly injected with mixtures of BoNT/A + BoNT/E. Compound muscular action potential (CMAP) was measured at different time intervals and the percentage variation of CMAP (%CMAP) was calculated. Unexpectedly, a much faster recovery of %CMAP after BoNT/E injections was observed. Double poisoned EBD muscles recovered similarly to BoNT/E. So, a larger deletion of the SNAP-25 molecule caused by BoNT/E leads to a faster functional recovery.

摘要

A型和E型肉毒杆菌毒素（BoNT/A和BoNT/E）分别切割突触小体相关蛋白25（SNAP-25）的羧基末端，去除9个和26个残基。为了研究这些对同一靶分子的损伤的影响，11名志愿者在一只脚的趾短伸肌（EDB）中注射3 IU的BoNT/A，在对侧注射3 IU的BoNT/E。此外，7名志愿者同样注射了BoNT/A + BoNT/E的混合物。在不同时间间隔测量复合肌肉动作电位（CMAP），并计算CMAP的百分比变化（%CMAP）。出乎意料的是，观察到注射BoNT/E后%CMAP的恢复要快得多。双重中毒的EDB肌肉恢复情况与BoNT/E相似。因此，由BoNT/E导致的SNAP-25分子更大的缺失导致功能恢复更快。