Arai H, Satoh-Nakagawa T, Higuchi M, Morikawa Y, Miura M, Kawakami H, Seki H, Takase S, Sasaki H
Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Miyagi, Japan.
Neurosci Lett. 1998 Nov 13;256(3):174-6. doi: 10.1016/s0304-3940(98)00781-2.
Tau protein levels in cerebrospinal fluid (CSF-tau) were determined in 29 patients with old cerebrovascular disease (CVD, 21 demented and eight non-demented), 69 patients with Alzheimer's disease (AD) and 17 age-matched normal controls. The CSF-tau level in the vascular dementia (VD) group (24.0 +/- 17.0 pg/ml) was significantly lower (P < 0.0001) than that in the AD group (90.0 +/- 45.3 pg/ml), but not significantly different from that in the non-demented patients with CVD (18.1 +/- 10.2 pg/ml) or controls (20.3 +/- 13.0 pg/ml). Among the VD patients, 1/21 exceeded a cut-off value (mean +/- 2 SD of controls), whereas 8/69 of the AD patients had CSF-tau levels below this value. These findings suggest that VD constitutes a group of dementias that can be separated from AD by normal CSF-tau levels. CSF-tau determinations in combination with other clinical findings may provide another diagnostic aid in the differential diagnosis between VD and AD.
对29例老年脑血管疾病（CVD，21例痴呆患者和8例非痴呆患者）、69例阿尔茨海默病（AD）患者以及17例年龄匹配的正常对照者测定了脑脊液中tau蛋白水平（CSF-tau）。血管性痴呆（VD）组的CSF-tau水平（24.0±17.0 pg/ml）显著低于AD组（90.0±45.3 pg/ml）（P<0.0001），但与非痴呆CVD患者（18.1±10.2 pg/ml）或对照组（20.3±13.0 pg/ml）无显著差异。在VD患者中，21例中有1例超过临界值（对照组均值±2SD），而AD患者中有69例中的8例CSF-tau水平低于此值。这些发现提示，VD构成了一组可通过正常CSF-tau水平与AD相鉴别的痴呆类型。CSF-tau测定结合其他临床发现可能为VD和AD的鉴别诊断提供另一项诊断依据。
