Siegrist C A, Córdova M, Brandt C, Barrios C, Berney M, Tougne C, Kovarik J, Lambert P H
WHO Collaborating Centre for Neonatal Vaccinology, Department of Pathology, University of Geneva, Switzerland.
Vaccine. 1998 Aug-Sep;16(14-15):1409-14. doi: 10.1016/s0264-410x(98)00100-5.
Presence of maternally-derived antibodies at time of immunization is known to often interfere with active infant immunization, although with variable degrees of clinical significance. In order to progressively decipher the rules that form the basis for these inhibitory effects on infant vaccine responses, two antigens (measles, tetanus) and various antigen presentation systems were evaluated in murine early life immunization models either in absence or presence of maternal antibodies. Both conventional (proteins, conjugate vaccines) and new (live viral vectors, DNA plasmids) antigen presentation systems were found to be similarly susceptible to the inhibitory influence of maternal antibodies. Factors emerging as crucial determinants of maternal antibody-mediated effects on responses to both live and non-live vaccines include (i) the level of maternal antibodies present at immunization, (ii) the use of distinct vaccines in mothers and pups and (iii) their distinct influence on B cell and T cell vaccine responses.
已知免疫时母体来源抗体的存在常常会干扰婴儿的主动免疫，尽管其临床意义程度不一。为了逐步解读构成这些对婴儿疫苗反应抑制作用基础的规则，在有无母体抗体的情况下，于小鼠早期生命免疫模型中评估了两种抗原（麻疹、破伤风）和各种抗原呈递系统。发现传统的（蛋白质、结合疫苗）和新的（活病毒载体、DNA质粒）抗原呈递系统同样易受母体抗体的抑制影响。作为母体抗体介导的对活疫苗和非活疫苗反应影响的关键决定因素出现的因素包括：（i）免疫时存在的母体抗体水平；（ii）母亲和幼崽使用不同的疫苗；以及（iii）它们对B细胞和T细胞疫苗反应的不同影响。
