Robbins J B, Schneerson R, Trollfors B, Taranger J, Lagergård T
National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA.
Dev Biol Stand. 1998;95:155-8.
Immunity conferred by vaccination with cellular pertussis vaccines and pertussis wanes so that adults are now the main reservoir of B. pertussis. Similar to diphtheria toxoid, acellular pertussis vaccines are suitable for vaccination of adults and it is probable that addition of pertussis toxoid to DT will be recommended for this age group. If this can be achieved, it is easy to predict that pertussis will be eliminated and the possibility of eradicating B. pertussis will become feasible. We propose that, despite the relative inaccuracy of correlating levels of antitoxin with individual immunity, a standardized assay and reference antiserum for pertussis toxoid will control acellular pertussis vaccines as was achieved with diphtheria toxoid.
用细胞百日咳疫苗和百日咳进行疫苗接种所赋予的免疫力会逐渐减弱，以至于成年人现在是百日咳博德特氏菌的主要储存宿主。与白喉类毒素类似，无细胞百日咳疫苗适用于成年人接种，并且很可能会建议在白喉破伤风联合疫苗（DT）中添加百日咳类毒素用于该年龄组。如果能够做到这一点，很容易预测百日咳将被消除，根除百日咳博德特氏菌的可能性将变得可行。我们建议，尽管将抗毒素水平与个体免疫力相关联存在相对不准确性，但针对百日咳类毒素的标准化检测方法和参考抗血清将像对白喉类毒素那样控制无细胞百日咳疫苗。
