Brinkhof M W, Daan S, Strubbe J H
Department of Animal Physiology, University of Groningen, Haren, The Netherlands.
Physiol Behav. 1998 Nov 15;65(2):225-31. doi: 10.1016/s0031-9384(98)00051-1.
To investigate the control over drinking and feeding behavior by the light-entrainable circadian pacemaker, rats were maintained in a 12 h:12 h skeleton photoperiod for 36 days with both food and water restricted to the subjective day. During the restriction period most of the food and water intake was concentrated during the first 4 h of the subjective day. The subsequent release into ad lib conditions under the skeleton photoperiod or continuous dark showed that this increased ingestion during the subjective day persisted for up to 6-10 days. This may indicate the entrainment of a food-entrainable oscillator, which has hitherto been investigated solely in anticipatory activity. The daily activity rhythm returned to its original phase position. Thus the phase of the overt daily rhythm is eventually only determined by the phase of the light-entrainable oscillator (LEO) but can temporarily be influenced by the restriction of food and water access. This restriction apparently stimulated a food-entrainable oscillator in antiphase with the light-entrainable oscillator but failed to phase shift or entrain the light-entrainable oscillator.
为了研究可被光调节的昼夜节律起搏器对饮水和进食行为的控制，将大鼠置于12小时光照：12小时骨架光周期环境中36天，食物和水都限制在主观白天供应。在限制期内，大部分食物和水的摄入集中在主观白天的前4小时。随后在骨架光周期或持续黑暗条件下恢复自由进食和饮水，结果显示在主观白天增加的摄入量持续了6至10天。这可能表明存在一个可被食物调节的振荡器，此前仅在预期活动中对其进行过研究。每日活动节律恢复到其原来的相位位置。因此，明显的每日节律的相位最终仅由可被光调节的振荡器（LEO）的相位决定，但可暂时受到食物和水获取限制的影响。这种限制显然刺激了一个与可被光调节的振荡器反相的可被食物调节的振荡器，但未能使可被光调节的振荡器发生相位移动或对其进行调节。
