Ballard C, Shaw F, McKeith I, Kenny R
Medical Research Council, Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne, UK.
Neurology. 1998 Dec;51(6):1760-2. doi: 10.1212/wnl.51.6.1760.
Orthostatic hypotension and carotid sinus hypersensitivity were assessed in patients meeting clinical criteria for dementia with Lewy bodies (DLB; n=30) and AD (n=35). Cardioinhibitory carotid sinus hypersensitivity (CI) was the most common sign (AD patients, 28%; DLB patients, 41%). Preliminary data from a secondary analysis excluding patients with hypertension or EKG evidence of ischemia suggested that CI may be significantly more common in DLB. Larger studies are needed to evaluate the implications for treatment and to explore the underlying mechanisms.
对符合路易体痴呆（DLB；n = 30）和阿尔茨海默病（AD；n = 35）临床标准的患者进行了直立性低血压和颈动脉窦超敏反应评估。心脏抑制性颈动脉窦超敏反应（CI）是最常见的体征（AD患者中占28%；DLB患者中占41%）。一项排除高血压患者或有缺血性心电图证据患者的二次分析的初步数据表明，CI在DLB中可能更为常见。需要开展更大规模的研究来评估其对治疗的影响并探索潜在机制。
