Abstract
Methylcobalamin is one of the two coenzyme forms of vitamin B12. Evidence indicates this form of vitamin B12, in addition to having a theoretical advantage over cyanocobalamin, actually has some metabolic and therapeutic applications not shared by the other forms of vitamin B12. This monograph provides an overview of the pharmacokinetics of methylcobalamin, and will highlight the potential therapeutic relevance for Bell's palsy, cancer, diabetic neuropathy, eye function, heart rate variability, HIV, homocysteinemia, male impotence, and sleep disorders.
摘要
甲钴胺是维生素B12的两种辅酶形式之一。有证据表明，这种形式的维生素B12除了在理论上比氰钴胺有优势外，实际上还有一些其他形式的维生素B12所没有的代谢和治疗应用。本专题论文概述了甲钴胺的药代动力学，并将重点阐述其在贝尔氏面瘫、癌症、糖尿病性神经病变、眼功能、心率变异性、艾滋病、高同型半胱氨酸血症、男性阳痿和睡眠障碍方面的潜在治疗意义。
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