Coaccioli S, Ponteggia F, Patucchi E, Di Cato L, Ponteggia M, Marioli D, Puxeddu A
Clinica Medica e Reumatologia, Scuola di Specializzazione in Reumatologia, Università degli Studi, Perugia.
Minerva Med. 1998 Sep;89(9):341-4.
The present study has been carried out in order to assess the clinical and functional efficacy and tolerability of galactosa-minoglucuronoglycan sulphate (GGGS). The molecule has been intra-articularly administered in patients affected by moderate primary gonarthritis, according to clinical and functional parameters.
At the beginning and at the end of each period of treatment the following parameters have been evaluated: spontaneous pain, provoked pain, pain during active movement, pain during passive movement, pain at rising (7-8:00 a.m.) pain at bed time (10:00 p.m.), execution time (expressed in seconds) of up-down from a chair (five times), execution time (expressed in seconds) to walk 15 meters. Fifty patients affected by osteoarthritis of the knee were treated weekly, during one year, for two periods of six weeks each with a total amount of 12 injections.
Treatment with Galactosaminglucuronoglycan sulphate (GGGS) seems to be effective in the therapy of osteoarthritis of the knee. The pain scores decreased and the functional levels significantly (p < 0.01) improved in a large proportion of patients and GGGS was very well tolerated.
This study suggests that intra-articular treatment is a substantially new way for GGGS administration in the therapy of osteoarthritis of the knee.
开展本研究是为了评估硫酸半乳糖氨基葡糖醛聚糖（GGGS）的临床和功能疗效及耐受性。根据临床和功能参数，已对中度原发性膝关节炎患者进行了该分子的关节内给药。
在每个治疗阶段开始和结束时，评估以下参数：自发痛、激发痛、主动运动时的疼痛、被动运动时的疼痛、起床时（上午7 - 8点）的疼痛、就寝时（晚上10点）的疼痛、从椅子上起坐（五次）的执行时间（以秒表示）、步行15米的执行时间（以秒表示）。50例膝骨关节炎患者接受为期一年的每周治疗，分两个为期六周的阶段，共注射12次。
硫酸半乳糖氨基葡糖醛聚糖（GGGS）治疗似乎对膝骨关节炎有效。在大部分患者中疼痛评分降低，功能水平显著（p < 0.01）改善，且GGGS耐受性良好。
本研究表明关节内治疗是GGGS用于膝骨关节炎治疗的一种全新给药方式。
