Pols H A
Afd. Inwendige Geneeskunde, Academisch Zickenhuis Rotterdam-Dijkzigt.
Ned Tijdschr Geneeskd. 1998 Aug 22;142(34):1902-3.
Over thirty years' research has failed to solve the controversy about use of fluoride in the treatment of osteoporosis. The marked increase of the mineral density of the bone in the lumbar spine is not unequivocally accompanied by a decrease of osteoporotic fractures. The therapeutic margin is narrow and there is no simple, validated method of dose adjustment. Consequently, fluoride should still be regarded as an experimental treatment, only to be used in the framework of clinical scientific research.
三十多年的研究未能解决关于使用氟化物治疗骨质疏松症的争议。腰椎骨矿物质密度显著增加，但骨质疏松性骨折并未明确减少。治疗范围狭窄，且没有简单、有效的剂量调整方法。因此，氟化物仍应被视为一种实验性治疗方法，仅在临床科研框架内使用。
