de Wit A C, Merkus J M
Academisch Ziekenhuis, afd. Gynaecologie en Obstetrie, Nijmegen.
Ned Tijdschr Geneeskd. 1998 Sep 19;142(38):2087-90.
The incidence of pregnancy complicated by melanoma of the skin, calculated from data of the Netherlands Cancer Registry, is 1 per 10,000 pregnancies. The prognosis of a melanoma is not affected by prior or subsequent pregnancy. A melanoma diagnosed during pregnancy does appear to have a more unfavourable prognosis, due not to a less favourable clinical course, but to a delay in diagnosing melanoma during pregnancy and (or) a less favourable site. When a pregnancy is complicated by malignancy, in case of a melanoma there is a higher risk of placental metastasis compared with other malignancies. In nearly 50% of the cases reported in literature of placental metastasis there was foetal involvement.
根据荷兰癌症登记处的数据计算,妊娠合并皮肤黑色素瘤的发病率为每10000次妊娠中有1例。黑色素瘤的预后不受既往或后续妊娠的影响。妊娠期诊断出的黑色素瘤预后似乎更差,这并非由于临床病程更不利,而是由于妊娠期黑色素瘤诊断延迟和(或)发病部位更不利。当妊娠合并恶性肿瘤时,与其他恶性肿瘤相比,黑色素瘤发生胎盘转移的风险更高。在文献报道的胎盘转移病例中,近50%有胎儿受累。