Koot R W, Portegies P
Afd. Neurochirurgie, Academisch Medisch Centrum/Universiteit van Amsterdam.
Ned Tijdschr Geneeskd. 1998 Sep 26;142(39):2129-32.
Two patients, a woman aged 65 years and a man aged 56 years, with cancer, presented with pain in one leg as the first manifestation of metastases. The woman had tumour plexopathy of the lumbosacral plexus caused by an os sacrum metastasis of a thyroid carcinoma; she received radiotherapy but died a short time later. The man had lumbosacral epidural metastases of a colon carcinoma, compressing lumbosacral roots; with radiotherapy he survived the first year. Back pain with radiating pain is a frequent symptom in patients with cancer. Spinal epidural metastases, spinal and paraspinal metastases without epidural extension, tumour plexopathy and leptomeningeal metastases are the commonest causes. Early diagnosis (by MRI or spinal fluid examination) is important; with progressive weakness or sphincter disturbances the prognosis worsens.
两名癌症患者，一名65岁女性和一名56岁男性，以单腿痛作为转移的首发表现。该女性因甲状腺癌骶骨转移导致腰骶丛肿瘤性神经病变；她接受了放疗，但不久后死亡。该男性患有结肠癌腰骶部硬膜外转移，压迫腰骶神经根；经放疗，他存活了一年。背痛伴放射痛是癌症患者的常见症状。脊髓硬膜外转移、无硬膜外扩展的脊柱和椎旁转移、肿瘤性神经病变和软脑膜转移是最常见的原因。早期诊断（通过MRI或脑脊液检查）很重要；随着病情进展出现肌无力或括约肌功能障碍，预后会恶化。
