Ajayi G O, Fadiran E O
Department of Obstetrics & Gynaecology, College of Medicine, University of Lagos, Idi-Araba, Lagos.
Clin Exp Obstet Gynecol. 1998;25(3):107-11.
A 61-day short-term prospective study comparing the efficacy of Chemiron capsules (Ferrous Fumarate 300 mg, Folic Acid 5 mg, Vitamin B12 10 ug, Vitamin C 25 mg, Magnesium sulphate, 0.3 mg and Zinc Sulphate 0.3 mg) with conventional ferrous gluconate and folic acid administration has shown that both haematinic regimens improve haematological indices in normal pregnant women. A significant rise in haemoglobin was seen in the Chemiron group on days 5 and 19 whereas a significant increase in packed cell volume was observed on days 5, 19 and 61. There were no significant differences between the mean value of platelets during the therapy period in either group. A significant rise in the mean reticulocyte values could be demonstrated in the Chemiron group throughout the study period. This study further shows that Chemiron has a better haematological effect than Ferrous Gluconate at the dosage used.
一项为期61天的短期前瞻性研究比较了Chemiron胶囊（富马酸亚铁300毫克、叶酸5毫克、维生素B12 10微克、维生素C 25毫克、硫酸镁0.3毫克和硫酸锌0.3毫克）与传统葡萄糖酸亚铁和叶酸给药的疗效，结果表明，两种补血方案均能改善正常孕妇的血液学指标。在第5天和第19天，Chemiron组的血红蛋白显著升高，而在第5天、第19天和第61天观察到红细胞压积显著增加。两组治疗期间血小板平均值无显著差异。在整个研究期间，Chemiron组的平均网织红细胞值显著升高。这项研究进一步表明，在所使用的剂量下，Chemiron比葡萄糖酸亚铁具有更好的血液学效果。
