Tomita H, Fuse S, Hatakeyama K, Suzuki M, Chiba S
Department of Pediatrics, Sapporo Medical University School of Medicine, Japan.
Jpn Circ J. 1998 Nov;62(11):807-10. doi: 10.1253/jcj.62.807.
Under continuous ECG and oxygen saturation (SpO2) monitoring, the following measurements were taken by Doppler echocardiography in 6 consecutive patients with tetralogy of Fallot (TF) before and after intravenous administration of disopyramide (2mg/kg): left ventricular shortening fraction (LVSF); peak velocities in the right ventricular outflow tract (RVOT); diastolic and systolic internal diameters of the right ventricular outflow tract (dRVOT, sRVOT); and systolic blood pressure. SpO2 increased (p<0.01) from 78 to 98 (89 +/- 7, mean +/- standard deviation)% to 86-99 (94 +/- 5)%. LVSF decreased (p<0.05) from 0.34-0.56 (0.42 +/- 0.08) to 0.22-0.54 (0.33 +/- 0.13). The systolic blood pressure fell slightly (p<0.05) from 68-92 (79 +/- 8) to 64-92 (71 +/- 11)mmHg. The sRVOT increased (p<0.05) from 2.1-4.8 (2.7 +/- 1.5)mm to 3.0-8.1 (4.9 +/- 2.4)mm, while RVOT peak velocity decreased (p<0.05) from 2.20-4.88 (3.70 +/- 0.97)m/sec to 2.05-4.07 (2.92 +/- 0.72)m/sec. Disopyramide alleviates hypoxia in patients of TF through its negative inotropic action on right ventricular outflow obstruction.
在持续心电图和血氧饱和度（SpO₂）监测下，对6例法洛四联症（TF）患者在静脉注射丙吡胺（2mg/kg）前后，采用多普勒超声心动图进行了以下测量：左心室缩短分数（LVSF）；右心室流出道（RVOT）的峰值速度；右心室流出道的舒张期和收缩期内径（dRVOT、sRVOT）；以及收缩压。SpO₂从78升至98（89±7，平均值±标准差）%，再升至86 - 99（94±5）%（p<0.01）。LVSF从0.34 - 0.56（0.42±0.08）降至0.22 - 0.54（0.33±0.13）（p<0.05）。收缩压从68 - 92（79±8）略降至64 - 92（71±11）mmHg（p<0.05）。sRVOT从2.1 - 4.8（2.7±1.5）mm增加至3.0 - 8.1（4.9±2.4）mm（p<0.05），而RVOT峰值速度从2.20 - 4.88（3.70±0.97）m/sec降至2.05 - 4.07（2.92±0.72）m/sec（p<0.05）。丙吡胺通过对右心室流出道梗阻的负性肌力作用减轻TF患者的缺氧症状。
