Waters J A
Department of Medicine, Imperial College School of Medicine, London, UK.
J Viral Hepat. 1998 Nov;5 Suppl 2:1-4. doi: 10.1046/j.1365-2893.1998.0050s2001.x.
In the murine model the immune response to both the hepatitis B envelope and nucleocapsid antigens are linked to the MHC class II haplotype but they are independently restricted. Although in a human outbred population non-response is less likely, the host genetic environment may be important in determining the level of response to vaccine and inclusion of antigens apart from the S antigen may improve protection. The inclusion of HBcAg in vaccine remains controversial since, despite its high immunogenicity, the Th-cell response to this antigen may have a role in the down regulation of the immune response to HBV so promoting persistence.
在小鼠模型中，对乙肝表面抗原和核衣壳抗原的免疫反应均与MHCⅡ类单倍型相关联，但它们受到独立限制。尽管在人类随机交配群体中无反应的可能性较小，但宿主遗传环境在决定对疫苗的反应水平方面可能很重要，并且除S抗原外加入其他抗原可能会增强保护作用。疫苗中加入核心抗原仍存在争议，因为尽管其免疫原性高，但对该抗原的Th细胞反应可能在下调对乙肝病毒的免疫反应从而促进病毒持续存在方面起作用。
