Howard C R
Department of Pathology and Infectious Diseases, Royal Veterinary College, London, UK.
J Viral Hepat. 1995;2(4):165-70. doi: 10.1111/j.1365-2893.1995.tb00024.x.
Accumulated evidence in recent years has shown that the variation of hepatitis B virus (HBV) genomes may have profound implications for our understanding of hepatitis B pathogenesis and prevention. Attention has focused on areas of the outer envelope coded by the S gene which are involved in the induction of a protective neutralising antibody response, and mutations which directly affect the production of C gene products, one of which is considered as a target for immune T cells involved in virus clearance. This review highlights recent experimental data which emphasizes the role of such mutations in the establishment and maintenance of chronic HBV infections and focuses attention on the significance of HBV variants with respect to the expanding use of HBV vaccines for mass immunization.
近年来积累的证据表明，乙型肝炎病毒（HBV）基因组的变异可能对我们理解乙型肝炎的发病机制和预防具有深远意义。注意力集中在由S基因编码的外膜区域，这些区域参与诱导保护性中和抗体反应，以及直接影响C基因产物产生的突变，其中一种C基因产物被认为是参与病毒清除的免疫T细胞的靶点。这篇综述强调了最近的实验数据，这些数据强调了此类突变在慢性HBV感染的建立和维持中的作用，并关注HBV变异体对于扩大使用HBV疫苗进行大规模免疫接种的意义。
