Simşek M, Naziroğlu M, Simşek H, Cay M, Aksakal M, Kumru S
Department of Obstetrics and Gynaecology, Firat University, Medical Faculty, Elaziğ, Turkey.
Cell Biochem Funct. 1998 Dec;16(4):227-31.
The plasma levels of lipoperoxides, glutathione peroxidase (GSH-Px), reduced glutathione (GSH), beta carotene, vitamin A, E, some plasma biochemical and blood haematological parameters were investigated in 40 women with habitual abortion (HA) and controls. The levels of GSH, vitamin A, E and beta carotene were significantly lower in women with HA than in controls. However, the plasma levels of lipid peroxidation, alkaline phosphatase (ALP), glucose and blood haemoglobin were significantly higher in HA than in controls. In addition, plasma levels of GSH-Px, AST, ALT, total bilirubin, total protein, albumin, sodium, potassium, calcium and number of white blood cells, red blood cells, platelet and values of packet cell volume showed no significant differences between HA and controls. According to the results of this study, we observed that the levels of lipid peroxidation were increased and plasma levels of vitamin A, E and beta carotene were decreased in HA. The decrease of those antioxidants may play a significant role in women with habitual abortion.
对40名习惯性流产（HA）女性及对照组女性的血浆脂质过氧化物、谷胱甘肽过氧化物酶（GSH-Px）、还原型谷胱甘肽（GSH）、β-胡萝卜素、维生素A、E水平以及一些血浆生化和血液学参数进行了研究。HA女性的GSH、维生素A、E和β-胡萝卜素水平显著低于对照组。然而，HA女性的血浆脂质过氧化、碱性磷酸酶（ALP）、葡萄糖和血红蛋白水平显著高于对照组。此外，HA组与对照组之间的血浆GSH-Px、AST、ALT、总胆红素、总蛋白、白蛋白、钠、钾、钙水平以及白细胞、红细胞、血小板数量和血细胞比容值均无显著差异。根据本研究结果，我们观察到HA女性的脂质过氧化水平升高，血浆维生素A、E和β-胡萝卜素水平降低。这些抗氧化剂的减少可能在习惯性流产女性中起重要作用。
