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[与渔民结婚的挪威女性甲状腺癌发病率上升]

[Increased incidence of thyroid cancer among Norwegian women married to fishermen].

作者信息

Frich L, Akslen L A, Glattre E

机构信息

Avdeling for patologi, Gades Institutt, Haukeland Sykehus, Bergen.

出版信息

Tidsskr Nor Laegeforen. 1998 Nov 10;118(27):4202-5.

PMID:9857802
Abstract

The relationship between thyroid cancer in women and the occupation of their spouses was examined in a retrospective cohort study. Of the 2.9 million women registered in the Central Population Registry of Norway by the end of 1991, 1.2 million had a spouse registered with an occupation in one or more of the censuses of 1960, 1970 or 1980. These women were included in the study. Based on the first digit of their husbands' five-digit Nordic occupational code, the women were assigned to ten broad categories. A standardised incidence ratio (SIR) and 95% confidence interval were calculated for each occupational category. The women were further subdivided and analysed in 71 groups defined by the first two digits of their husband's occupational code. Among the women included in the study, a total of 2,409 cases of thyroid cancer were reported to the Cancer Registry of Norway during the period 1960-92. A significantly elevated risk of thyroid cancer was found only among women whose spouses belonged to the occupational category Agriculture, forestry or fishery (n = 208,279), with a SIR of 1.13. In the subgroup Fishing, whaling and sealing work (n = 40,839), the risk was even higher with a standardised incidence ratio of 1.91. Our data support the proposed relationship between increased risk of thyroid cancer and mode of living, more specifically dietary fish or other seafood.

摘要

在一项回顾性队列研究中,对女性甲状腺癌与其配偶职业之间的关系进行了调查。截至1991年底,在挪威中央人口登记处登记的290万女性中,有120万女性的配偶在1960年、1970年或1980年的一次或多次人口普查中登记了职业。这些女性被纳入研究。根据其丈夫五位数字的北欧职业代码的首位数字,将这些女性分为十大类。计算了每个职业类别的标准化发病率(SIR)和95%置信区间。这些女性进一步细分为71组,根据其丈夫职业代码的前两位数字进行定义。在纳入研究的女性中,1960年至1992年期间,挪威癌症登记处共报告了2409例甲状腺癌病例。仅在配偶属于农业、林业或渔业职业类别的女性中发现甲状腺癌风险显著升高(n = 208,279),标准化发病率为1.13。在捕鱼、捕鲸和海豹捕猎工作亚组(n = 40,839)中,风险更高,标准化发病率为1.91。我们的数据支持了甲状腺癌风险增加与生活方式之间的关系,更具体地说是饮食中的鱼类或其他海鲜。

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