小鼠冠状病毒DVIM的血凝素酯酶和刺突糖蛋白的一级结构
Primary structures of hemagglutinin-esterase and spike glycoproteins of murine coronavirus DVIM.
作者信息
Morita E, Ebina H, Muto A, Himeno H, Hatakeyama K, Sugiyama K
机构信息
Department of Biology, Faculty of Science, Hirosaki University, Japan.
出版信息
Virus Genes. 1998;17(2):123-8. doi: 10.1023/a:1008060522426.
Diarrhea virus of infant mice (DVIM) is a member of murine hepatitis viruses (MHVs). The nucleotide sequences of the genes encoding the hemagglutinin-esterase (HE) and the spike (S) glycoproteins from DVIM were determined and compared with those of other MHVs. The deduced amino acid sequence of the HE protein was most similar to that of MHV-S strain (94% identity), and the S protein sequence was most similar to that of MHV-Y strain (90% identity). The DVIM HE protein has a unique N-linked glycosylation site in addition to other glycosylation sites common to many MHV strains. Unlike in some typical MHV strain, such as MHV-A59 and MHV-JHM, the vast majority of the S glycoprotein molecules in DVIM exist an uncleaved form probably due to several amino acid substitutions around the cleavage site.
幼鼠腹泻病毒（DVIM）是鼠肝炎病毒（MHV）的一种。测定了DVIM编码血凝素酯酶（HE）和刺突（S）糖蛋白的基因的核苷酸序列，并与其他MHV的序列进行了比较。推导的HE蛋白氨基酸序列与MHV-S株最相似（同一性为94%），S蛋白序列与MHV-Y株最相似（同一性为90%）。除了许多MHV株共有的其他糖基化位点外，DVIM的HE蛋白还有一个独特的N-连接糖基化位点。与一些典型的MHV株（如MHV-A59和MHV-JHM）不同，DVIM中绝大多数S糖蛋白分子可能由于切割位点周围的几个氨基酸取代而以未切割形式存在。
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