未能在双相II型障碍的传递中证明亲本来源效应。
Failure to demonstrate parent-of-origin effect in transmission of bipolar II disorder.
作者信息
Kato T, Winokur G, Coryell W, Rice J, Endicott J, Keller M B, Akiskal H S
机构信息
Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242-1000, USA.
出版信息
J Affect Disord. 1998 Sep;50(2-3):135-41. doi: 10.1016/s0165-0327(97)00102-x.
BACKGROUND
Parent-of-origin effect (POE) is suggested in transmission of bipolar disorder. Bipolar II disorder (BPII) should be considered separately.
METHODS
The gender difference of transmitting parents, prevalence rate in children, and age at onset of patients in relation to the sex of the transmitting parent, were examined in 220 BPII patients.
RESULTS
No evidence suggesting involvement of POE was found.
CONCLUSION
POE is not involved in transmission of BPII.
LIMITATION
Number of subjects is not sufficient. Rate of interviewed subjects differs between mothers and fathers.
CLINICAL RELEVANCE
Female BPII patients do not transmit the disease more often than male patients.
背景
双相情感障碍的遗传中存在亲源效应（POE）。双相II型障碍（BPII）应单独考虑。
方法
对220例BPII患者进行研究，分析传递亲本的性别差异、子代患病率以及患者发病年龄与传递亲本性别的关系。
结果
未发现亲源效应参与其中的证据。
结论
亲源效应不参与BPII的遗传传递。
局限性
样本数量不足。父母的访谈率存在差异。
临床意义
女性BPII患者并不比男性患者更易传递该疾病。
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