Ehret J M, Judson F N
Denver Department of Public Health, University of Colorado Health Sciences Center, 80204-4507, USA.
Sex Transm Dis. 1998 Nov;25(10):522-6. doi: 10.1097/00007435-199811000-00005.
Fluoroquinolones are one of the most widely used treatments for gonorrhoeae. Changes in the susceptibility of Neisseria gonorrhoeae to these agents may threaten their use.
To report several resistant strains (>1 mcg/ml) isolated in the western United States and to evaluate the prevalence of strains with reduced susceptibility (ofloxacin 0.25 mcg/ml, ciprofloxacin 0.06 mcg/ml).
The microbiology and epidemiology of three resistant strains were characterized and 12,761 other strains were evaluated for fluoroquinolone susceptibility as part of the Gonococcal Isolate Surveillance Project of the Centers for Disease Control and Prevention.
Fluoroquinolone-resistant strains may appear sporadically. The prevalence of isolates with reduced susceptibility to fluoroquinolones remains low in the Southwest region of the United States.
Continued active surveillance is needed to detect and control the spread of quinolone-resistant Neisseria gonorrhoeae.
氟喹诺酮类药物是淋病最常用的治疗药物之一。淋病奈瑟菌对这些药物敏感性的变化可能会威胁到它们的使用。
报告在美国西部分离出的几株耐药菌株（>1微克/毫升），并评估敏感性降低菌株（氧氟沙星0.25微克/毫升，环丙沙星0.06微克/毫升）的流行情况。
对三株耐药菌株的微生物学和流行病学特征进行了描述，并作为疾病控制和预防中心淋球菌分离株监测项目的一部分，对另外12761株菌株的氟喹诺酮敏感性进行了评估。
耐氟喹诺酮菌株可能偶尔出现。在美国西南部地区，对氟喹诺酮敏感性降低的分离株的流行率仍然较低。
需要持续进行积极监测，以检测和控制耐喹诺酮淋病奈瑟菌的传播。
