Gragnaniello D, Kessler J, Bley M, Mielke R
Universitá di Ferrara, Clinica Neurologica, Italien.
Nervenarzt. 1998 Nov;69(11):991-8. doi: 10.1007/s001150050374.
In this study we assessed the drawing abilities in 37 patients with probable Alzheimer's disease according to NINCDS-ADRDA criteria. Drawing abilities (drawing: house, flower, clock; Rey-Osterrieth figure; copying: MMST-figure; Rey-Osterrieth figure) were quantified with different rating schemes and related to other neuropsychological assessments. All patients underwent a positron emission tomography with 18-FDG. Drawing performance was highly correlated with severity of dementia--expressed in MMST scores (r = 0.78; p < 0.0001)--with visuo-spatial short-term memory (r = -0.69; p = 0.001), and writing abilities (r = -0.77; p < 0.0001). The summarized drawing score showed a statistically significant correlation with the rate of temporoparietal glucose metabolism measured with positron emission tomography and 18-FDG (r = 0.39; p = 0.017). In the drawings of AD patients omittings and simplifications were typical, whereas perseverations rarely occurred. In severely demented patients closing-in phenomenons could be described, too. A subgroup of AD patients with visuo-constructive impairment as the leading symptom could not be identified.
在本研究中，我们根据NINCDS - ADRDA标准评估了37例可能患有阿尔茨海默病的患者的绘图能力。绘图能力（绘图：房屋、花朵、时钟；雷 - 奥斯特里思图形；临摹：简易精神状态检查表图形；雷 - 奥斯特里思图形）采用不同的评分方案进行量化，并与其他神经心理学评估相关联。所有患者均接受了18 - FDG正电子发射断层扫描。绘图表现与痴呆严重程度高度相关——以简易精神状态检查表分数表示（r = 0.78；p < 0.0001），与视觉空间短期记忆（r = -0.69；p = 0.001）以及书写能力（r = -0.77；p < 0.0001）相关。汇总的绘图分数与通过正电子发射断层扫描和18 - FDG测量的颞顶叶葡萄糖代谢率具有统计学显著相关性（r = 0.39；p = 0.017）。在阿尔茨海默病患者的绘图中，遗漏和简化很典型，而持续现象很少发生。在严重痴呆的患者中，也可以描述封闭现象。未发现以视觉构建障碍为主要症状的阿尔茨海默病患者亚组。
