Lin Ker-Neng, Wang Pei-Ning, Chen Chien, Chiu Yu-Hong, Kuo Chi-Chung, Chuang Ya-Yun, Liu Hsiu-Chih
Neurological Institute, Taipei Veterans General Hospital and Department of Neurology, National Yang-Ming University School of Medicine, Taipei, Taiwan.
Eur Neurol. 2003;49(1):53-8. doi: 10.1159/000067026.
The Clock-Drawing Test (CDT) has been used to screen for Alzheimer's disease (AD) as a supplement to cognitive tests that focus on memory impairment. We examined a comprehensive scoring system of the CDT in screening of AD in a Chinese population and derived a simplified scoring system. All 403 (144 AD and 259 nondemented) subjects were administered the CDT, including both the drawing part (CDT-D) and the copying part (CDT-C). The Cognitive Abilities Screening Instrument and the Clinical Dementia Rating were also administered. Stepwise discriminant analysis was used to develop a simplified CDT scoring system. The optimal CDT cutoff scores (CDT-D: 10/11; CDT-C: 12/13) show intermediate sensitivity (CDT-D: 66.7%; CDT-C: 51.4%) and specificity (CDT-D: 74.5%; CDT-C: 74.1%). The simplified 3-item CDT scoring system, with a cutoff score of 2/3, has a sensitivity of 72.9% and a specificity of 65.6%; it can be used as a quick test for AD screening.
画钟试验（CDT）已被用于作为针对侧重于记忆障碍的认知测试的补充，来筛查阿尔茨海默病（AD）。我们在中国人群中检验了CDT的一种综合评分系统，并得出了一种简化评分系统。对所有403名受试者（144名AD患者和259名非痴呆者）进行了CDT测试，包括绘图部分（CDT-D）和临摹部分（CDT-C）。还进行了认知能力筛查工具测试和临床痴呆评定。采用逐步判别分析来建立简化的CDT评分系统。最佳的CDT临界分数（CDT-D：10/11；CDT-C：12/13）显示出中等的敏感性（CDT-D：66.7%；CDT-C：51.4%）和特异性（CDT-D：74.5%；CDT-C：74.1%）。简化的3项CDT评分系统，临界分数为2/3，敏感性为72.9%，特异性为65.6%；它可作为AD筛查的快速测试。
