[BTA Stat检测（巴德公司）在膀胱癌诊断中的应用。初步结果及与细胞学检查和膀胱镜检查的比较]

[Usefulness of BTA Stat test (Bard) in the diagnosis of bladder cancer. Preliminary results and comparison with cytology and cystoscopy].

作者信息

Gutiérrez Baños J L, Martín García B, Hernández Rodríguez R, Portillo Martín J A, Correas Gómez M A, del Valle Schaan J I, Roca Edreira A, Villanueva Peña A, Gutíerrez García R, De Diego Rodríguez E, Rado Velázquez M A

机构信息

Servicio de Urología, Hospital Universitario Valdecilla, Santander, España.

出版信息

Arch Esp Urol. 1998 Oct;51(8):778-82.

PMID:9859583

Abstract

OBJECTIVE

The Bard BTA test is an immunochromatographic reaction to detect the bladder tumor antigen in patients with bladder cancer. The sensitivity, specificity and predictive values of this test are analyzed and compared with the standard methods of bladder cancer diagnosis (cystoscopy and cytology).

METHODS

In 120 patients with symptoms suggestive of bladder cancer or who came for follow-up control evaluation for bladder cancer, we performed the BTA test and cytology in a voided urine sample prior to cystoscopy. TUR and randomized biopsies were performed in patients with a suspicion of bladder cancer.

RESULTS

76 patients had bladder cancer and 44 were free of cancer. The sensitivity was 76.36% for the BTA test, 61.84% for cytology and 98.5% for cystoscopy. The specificity was 77.7% for the BTA test, 86.36% for cytology and 86.36% for cystoscopy. The positive and negative predictive values were 85.29% and 65.38%, 88.68% and 56.72%, and 91.5% and 97.4%, respectively, for each of the foregoing tests. The sensitivity by grade was 43.75% for G1, 78.38% for G2, 95.65% for G3 for the BTA test; 18.75%, 59.46% and 95.65% for G1, G2 and G3, respectively, for cytology. The sensitivity by stage was 53.8% for Ta, 76% for T1, and 100% for T2-4 and Tis for the BTA test, whereas the sensitivity for cytology was 23.08%, 62% and 100%, respectively, for the foregoing tumor stages.

CONCLUSIONS

The BTA test is simple, fast and useful in bladder cancer diagnosis. Our results show that the BTA test is superior to cytology.

摘要

目的

Bard BTA检测是一种免疫层析反应，用于检测膀胱癌患者的膀胱肿瘤抗原。分析该检测的敏感性、特异性和预测值，并与膀胱癌诊断的标准方法（膀胱镜检查和细胞学检查）进行比较。

方法

对120例有膀胱癌症状或前来进行膀胱癌随访控制评估的患者，在膀胱镜检查前对其晨尿样本进行BTA检测和细胞学检查。对疑似膀胱癌的患者进行经尿道切除术（TUR）和随机活检。

结果

76例患者患有膀胱癌，44例无癌症。BTA检测的敏感性为76.36%，细胞学检查为61.84%，膀胱镜检查为98.5%。BTA检测的特异性为77.7%，细胞学检查为86.36%，膀胱镜检查为86.36%。上述每项检测的阳性预测值和阴性预测值分别为85.29%和65.38%、88.68%和56.72%、91.5%和97.4%。BTA检测按分级的敏感性，G1为43.75%，G2为78.38%，G3为95.65%；细胞学检查G1、G2和G3分别为18.75%、59.46%和95.65%。BTA检测按分期的敏感性，Ta为53.8%，T1为76%，T2-4和Tis为100%；而上述肿瘤分期的细胞学检查敏感性分别为23.08%、62%和100%。