源自苯并咪唑的1,3,4-噻二唑、咪唑并[2,1-b]1,3,4-噻二唑和噻二唑并[3,2-a]嘧啶作为潜在抗菌剂的合成。
Synthesis of 1,3,4-thiadiazoles, imidazo[2,1-b]1,3,4-thiadiazoles and thiadiazolo[3,2-a]pyrimidines derived from benzimidazole as potential antimicrobial agents.
作者信息
Ashour F A, Habib N S, el Taibbi M, el Dine S, el Dine A S
机构信息
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt.
出版信息
Farmaco. 1990 Dec;45(12):1341-9.
PMID:2090143
Abstract
Several new 1,3,4-thiadiazole, imidazo[2,1-b]1,3,4-thiadiazole and thiadiazole[3,2-al]pyrimidine derivatives of benzimidazole were synthesized. The compounds were obtained from 1-ethyl or benzyl 2-(2-amino-1,3,4-thiadiazol-5-yl)thiomethylbenzimidazole. The antimicrobial activity of the prepared compounds was studied.
摘要
合成了几种新型的苯并咪唑的1,3,4-噻二唑、咪唑并[2,1-b]1,3,4-噻二唑和噻二唑并[3,2-a]嘧啶衍生物。这些化合物由1-乙基或苄基2-(2-氨基-1,3,4-噻二唑-5-基)硫代甲基苯并咪唑制得。研究了所制备化合物的抗菌活性。
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