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[硫酸氨基胍治疗黏膜利什曼病:两年随访结果]

[Treatment of mucosal leishmaniasis with aminosidine sulfate: results of two year follow-up].

作者信息

Romero G A, Lessa H A, Orge M G, Macêdo V O, Marsden P D

机构信息

Núcleo de Medicina Tropical e Nutrição/Universidade de Brasília.

出版信息

Rev Soc Bras Med Trop. 1998 Nov-Dec;31(6):511-6. doi: 10.1590/s0037-86821998000600001.

Abstract

In 1996, 20 of 21 patients with mucosal leishmaniasis, treated in 1994 with aminosidine sulfate, 16mg/kg/day salt, by intramuscular injection for 20 days, were clinically evaluated. One patient died due to disease not related to mucosal leishmaniasis. Seven of 14 patients (66.7% N = 21) who achieved complete remission three months after treatment remained clinically cured 24 months later and seven relapsed in the same period (50% N = 14). Sorological follow-up showed poor correlation with the results of clinical examination.

摘要

1994年,21例黏膜利什曼病患者接受了硫酸氨基糖苷治疗,剂量为16mg/kg/天盐,肌肉注射20天。1996年,对这些患者进行了临床评估。1例患者因与黏膜利什曼病无关的疾病死亡。14例在治疗三个月后实现完全缓解的患者中,7例(66.7%,N = 21)在24个月后仍临床治愈,7例在同一时期复发(50%,N = 14)。血清学随访显示与临床检查结果的相关性较差。

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