Scher H, Miller Y E, Aguayo S M, Johnson K J, Miller J E, McCray P B
Department of Pediatrics, University of Iowa College of Medicine, Iowa City 52242-1083, USA.
Pediatr Pulmonol. 1998 Nov;26(5):326-31. doi: 10.1002/(sici)1099-0496(199811)26:5<326::aid-ppul4>3.0.co;2-s.
Compared to normal infants and children, there are increased numbers of neuroendocrine cells with bombesin-like peptide (BLP) immunostaining in the lungs of infants and children with bronchopulmonary dysplasia (BPD) and cystic fibrosis (CF). However, there are no data documenting levels of urinary BLP in normal infants and children, or in children with lung disease. We therefore determined the normal developmental pattern for urinary BLP excretion in healthy infants and children, and in infants and children with BPD and CF, and correlated these findings with the subjects' clinical course. We measured urinary BLP levels in 110 subjects: 54 controls, 33 with BPD, and 23 with CF. An age-dependent decline in urinary bombesin levels was evident in the control and BPD subjects, but not in those with CF. There were no statistically significant differences in BLP levels between normal infants and those with BPD. Mean BLP levels were higher in the more immature preterm infants with BPD who required increased ventilatory support. The highest mean BLP levels were documented in BPD infants under age 3 months (882 fmol/mg creatinine), in controls between 3 and 12 months of age (625 fmol/mg creatinine), and in 12-60-month-old CF subjects (486 fmol/mg creatinine). Thus there is an age-dependent decline in BLP levels in controls and BPD, but not in CF. We speculate that the elevated urinary BLP levels in infants and children with BPD and CF may reflect increased pulmonary neuroendocrine cell activity in these conditions, due to the epithelial regenerative response to airway damage and repair.
与正常婴幼儿相比，支气管肺发育不良（BPD）和囊性纤维化（CF）的婴幼儿肺部中，具有胃泌素释放肽样肽（BLP）免疫染色的神经内分泌细胞数量增多。然而，尚无数据记录正常婴幼儿以及患有肺部疾病的儿童的尿BLP水平。因此，我们确定了健康婴幼儿、患有BPD和CF的婴幼儿尿BLP排泄的正常发育模式，并将这些发现与受试者的临床病程相关联。我们测量了110名受试者的尿BLP水平：54名对照者、33名患有BPD者和23名患有CF者。在对照者和患有BPD的受试者中，尿胃泌素释放肽水平呈现出年龄依赖性下降，但在患有CF的受试者中并非如此。正常婴幼儿与患有BPD的婴幼儿之间的BLP水平无统计学显著差异。需要增加通气支持的、更不成熟的早产BPD婴幼儿的平均BLP水平更高。3个月以下的BPD婴幼儿（882 fmol/mg肌酐）、3至12个月大的对照者（625 fmol/mg肌酐）以及12至60个月大的CF受试者（486 fmol/mg肌酐）的平均BLP水平最高。因此，对照者和患有BPD的受试者中BLP水平存在年龄依赖性下降，但患有CF的受试者中并非如此。我们推测，患有BPD和CF的婴幼儿尿BLP水平升高可能反映了在这些情况下肺神经内分泌细胞活性增加，这是由于上皮对气道损伤和修复的再生反应所致。
