Holmgren N L, Faro A, Gondor M I, Orenstein D M
Division of Pulmonology, Department of Pediatrics, University of Miami, Miami, Florida 32610, USA.
Pediatr Pulmonol. 2001 Jun;31(6):474-7. doi: 10.1002/ppul.1077.
Cystic fibrosis (CF) and bronchopulmonary dysplasia (BPD) are two common causes of chronic lung disease in children. Patients with BPD or CF often have recurrent respiratory symptoms, failure to thrive, and/or metabolic alkalosis during infancy and childhood. Thus, recognizing the diagnosis of CF in an infant with BPD can be difficult. We present three infants with both BPD and CF. The infants shared a history of respiratory distress and prolonged oxygen requirements. All three also had difficulty gaining weight, even after pancreatic enzyme supplementation was instituted. Metabolic alkalosis was observed in two infants. Previous studies in children with CF suggest that early diagnosis may impact both lung health and nutritional status. A high index of suspicion is necessary for clinicians to identify these children early and intervene with appropriate therapy.
囊性纤维化（CF）和支气管肺发育不良（BPD）是儿童慢性肺病的两个常见病因。患有BPD或CF的患者在婴儿期和儿童期常常出现反复的呼吸道症状、生长发育迟缓及/或代谢性碱中毒。因此，在患有BPD的婴儿中识别CF的诊断可能很困难。我们报告了三名同时患有BPD和CF的婴儿。这些婴儿都有呼吸窘迫病史且长期需要吸氧。即便在补充胰酶后，所有三名婴儿体重增加仍有困难。两名婴儿出现了代谢性碱中毒。先前针对CF患儿的研究表明，早期诊断可能会影响肺部健康和营养状况。临床医生需要高度怀疑，以便尽早识别这些儿童并进行适当治疗干预。
