Isgreen W P
Neurology. 1976 Sep;26(9):825-34. doi: 10.1212/wnl.26.9.825.
A boy with neonatal and childhood convulsions had prolonged attacks of tetany in adolescence. There was no abnormality of serum calcium or magnesium, and treatment with these cations was ineffective. There was no respiratory alkalosis, and attacks occurred when the patient had not taken anticonvulsant drugs for years. Serum parathormone content and renal responses to the administration of parathormone were normal. "Normocalcemic tetany" seems an appropriate name for the condition, which was probably genetic since the patient's brother and mother had signs of latent tetany and the brother had a convulsive disorder. The cause of the syndrome is not known, but it seems to be an abnormal response of neural membranes rather than an abnormality of calcium homeostasis.
一名患有新生儿期和儿童期惊厥的男孩在青春期出现了持续性手足搐搦发作。血清钙和镁无异常，用这些阳离子进行治疗无效。无呼吸性碱中毒，且在患者多年未服用抗惊厥药物时发作仍会出现。血清甲状旁腺激素含量及肾脏对甲状旁腺激素给药的反应均正常。“正常血钙性手足搐搦”似乎是该病症的一个恰当名称，其可能具有遗传性，因为患者的兄弟和母亲有隐匿性手足搐搦的体征，且兄弟患有惊厥性疾病。该综合征的病因尚不清楚，但似乎是神经膜的异常反应而非钙稳态异常。
