Fonager K, Sørensen H T, Olsen J, Dahlerup J F, Rasmussen S N
The Danish Epidemiology Science Centre at the Department of Epidemiology and Social Medicine, University of Aarhus.
Am J Gastroenterol. 1998 Dec;93(12):2426-30. doi: 10.1111/j.1572-0241.1998.00698.x.
Crohn's disease, characterized by chronic intestinal inflammation, is sometimes followed by malabsorption, which may interfere with embryogenesis and fetal growth. Therefore we examined birthweight, the frequency of preterm birth, and other reproductive outcomes in the offspring of women with Crohn's disease.
We used a historical registry-based study, with linkage between the Danish National Registry of Patients and the Danish Medical Birth Registry. Included were 510 newborns to mothers with Crohn's disease and 3018 controls in the study period from 1982 to 1992.
The average birthweight of newborns to mothers with Crohn's disease was 185 g, 134 g less than expected for primiparas and multiparas. After adjusting for potential confounders the differences were 142 g (95% confidence interval [CI95%] = 76, 208) and 105 g (CI95% = 37, 173), respectively. The risk of low birthweight was increased in Crohn patients (odds ratio [OR] = 2.4; CI95% = 1.6-3.7), as was the risk of preterm birth (OR = 1.6; CI95% = 1.1-2.3).
We found a lower birthweight in newborns of patients with Crohn's disease, indicating that Crohn's disease or its treatment may influence fetal growth.
克罗恩病以慢性肠道炎症为特征，有时会继发吸收不良，这可能会干扰胚胎发育和胎儿生长。因此，我们研究了克罗恩病女性患者后代的出生体重、早产频率及其他生殖结局。
我们采用基于历史登记的研究方法，将丹麦国家患者登记处与丹麦医学出生登记处进行了关联。研究期间为1982年至1992年，纳入了510名克罗恩病母亲所生的新生儿和3018名对照。
克罗恩病母亲所生新生儿的平均出生体重为185克，比初产妇和经产妇预期的体重轻134克。在对潜在混杂因素进行调整后，差异分别为142克（95%置信区间[CI95%]=76,208）和105克（CI95%=37,173）。克罗恩病患者低出生体重的风险增加（优势比[OR]=2.4；CI95%=1.6 - 3.7），早产风险也增加（OR = 1.6；CI95% = 1.1 - 2.3）。
我们发现克罗恩病患者的新生儿出生体重较低，这表明克罗恩病或其治疗可能会影响胎儿生长。
