Mendler M H, Bouillet P, Sautereau D, Chaumerliac P, Cessot F, Le Sidaner A, Pillegand B
Am J Gastroenterol. 1998 Dec;93(12):2482-90. doi: 10.1111/j.1572-0241.1998.00708.x.
The aim of this study was to evaluate magnetic resonance cholangiography (MRC) in the diagnosis of biliary tree obstruction.
Fifty-eight consecutive patients underwent MRC (GYROSCAN ACS II 1.5 Tesla, TSE T2 axial/coronal-MIP sequences) for clinical and biochemical signs of main bile duct obstruction. MRC images were interpreted by two radiologists and consensus was established according to presence or absence of main bile duct dilation, choledocholithiasis, and malignant or benign stricture. MRC was compared to a final diagnosis established by ultrasound and CT in 19 cases, endoscopic retrograde cholangiopancreatography (ERCP) in 25, intraoperative cholangiography and exploration in 14, and clinical, biochemical, and histological presentation when relevant. Included were single or multiple choledocholithiasis (28, including 11 < or = 3 mm), malignant (10) and benign (12) strictures, and intrahepatic cholestasis (9).
Overall, MRC was sensitive (94%) and specific (92%) in detecting main bile duct dilation and choledocholithiasis (86 % and 97 %), but was less sensitive (64%) for small stones < or = 3 mm. Sensitivity for stones > 3 mm was 100%. For benign and malignant strictures, MRC was less sensitive (67% and 80%) but remained specific (98% and 96%). In the detection of normal main bile duct, MRC was highly sensitive (100%) and specific (94%). Diagnostic accuracy ranged from 91% to 98%.
MRC appears to be specific for choledocholithiasis and sensitive except for small stones. Results for biliary stricture are less satisfactory, but remain specific. Our data confirm that MRC can be useful in the diagnostic workup of main bile duct obstruction.
本研究旨在评估磁共振胆胰管造影(MRC)在胆管梗阻诊断中的应用。
58例连续患者因出现肝外胆管梗阻的临床及生化表现而接受MRC检查(采用飞利浦GYROSCAN ACS II 1.5T磁共振成像仪,TSE T2加权轴位/冠状位-MIP序列)。由两名放射科医生解读MRC图像,并根据肝外胆管是否扩张、是否存在胆总管结石以及狭窄是恶性还是良性达成共识。将MRC结果与19例患者的超声及CT最终诊断结果、25例患者的内镜逆行胰胆管造影(ERCP)结果、14例患者的术中胆管造影及探查结果以及相关情况下的临床、生化及组织学表现进行比较。其中包括单发或多发胆总管结石(28例,包括11例直径≤3mm的结石)、恶性狭窄(10例)、良性狭窄(12例)以及肝内胆汁淤积(9例)。
总体而言,MRC在检测肝外胆管扩张及胆总管结石方面具有较高的敏感性(94%)和特异性(92%)(检测胆总管结石的敏感性和特异性分别为86%和97%),但对于直径≤3mm的小结石敏感性较低(64%)。对于直径>3mm的结石,敏感性为100%。对于良性和恶性狭窄,MRC的敏感性较低(分别为67%和80%),但特异性仍然较高(分别为98%和96%)。在检测正常肝外胆管方面,MRC具有较高的敏感性(100%)和特异性(94%)。诊断准确率在91%至98%之间。
MRC对胆总管结石具有较高的特异性,除小结石外敏感性较高。对于胆管狭窄的诊断结果虽不太令人满意,但仍具有较高的特异性。我们的数据证实,MRC在肝外胆管梗阻的诊断检查中具有重要作用。