Challis J R, Forster C S, Furr B J, Robinson J S, Thorburn G D
Prostaglandins. 1976 Mar;11(3):537-43. doi: 10.1016/0090-6980(76)90102-7.
A single injection (100 mug i.m.) of Estrumate (I.C.I. 80996) was used to induce luteal regression on day 8 of the estrous cycle in 3 sheep. Progesterone levels in the utero-ovarian vein and femoral artery had fallen within 6 h to less than 50% of the concentrations seen before injection of the analogue. Luteolysis was not associated with endogenous production of PGF. The concentration of PGF in the uteroovarian vein began to increase 27-39 h after the administration of Estrumate, reaching a mean maximum concentration of 1455pg/ml 48 h after Estrumate. The mean concentration of PGF in the utero-ovarian vein between 36-69 h after Estrumate was significantly greater than during the 24 h before Estrumate (control period) or during the 0-30 h immediately after injection (both P less than 0.001). The maximum secretion of estradiol and the pre-ovulatory LH peak occurred during the period of elevated PGF concentrations in the utero-ovarian veins. The possible importance of endogenous PGF production at this time is discussed.
对3只绵羊在发情周期的第8天单次肌肉注射（100微克）氯前列醇（ICI 80996）以诱导黄体退化。子宫卵巢静脉和股动脉中的孕酮水平在6小时内降至注射类似物前浓度的50%以下。黄体溶解与内源性前列腺素F（PGF）的产生无关。在注射氯前列醇后27 - 39小时，子宫卵巢静脉中的PGF浓度开始升高，在注射氯前列醇后48小时达到平均最高浓度1455皮克/毫升。在注射氯前列醇后36 - 69小时之间，子宫卵巢静脉中PGF的平均浓度显著高于注射氯前列醇前24小时（对照期）或注射后立即的0 - 30小时（两者P均小于0.001）。在子宫卵巢静脉中PGF浓度升高期间出现了雌二醇的最大分泌和排卵前促黄体生成素峰值。讨论了此时内源性PGF产生的可能重要性。
