White R E
Department of Drug Metabolism and Pharmacokinetics, Schering-Plough Research Institute, Kenilworth, NJ 07033-1300, USA.
Drug Metab Dispos. 1998 Dec;26(12):1213-6.
The science of drug metabolism, like any other science, has advanced from simple beginnings (by today's standards) to its present state. One can examine the path that has been taken to understand the forces driving the direction of evolution of this science. The trends discovered can then be used to make reasonable extrapolations about the changes that might be expected in the future. That exercise is the subject of this article. The main focus will be on drug metabolism as practiced in the industrial environment, representing the author's main experience as well as the principal arena of practical applications of the science. The discussion will draw mainly on broad phenomena occurring in this application of drug metabolism to drug discovery and development.
药物代谢科学与其他任何科学一样，已从（以当今标准衡量）简单的开端发展到了目前的状态。人们可以审视其发展历程，以理解推动这门科学演变方向的各种力量。然后，所发现的趋势可用于对未来可能出现的变化进行合理推断。本文的主题正是此项探讨。主要关注点将是工业环境中的药物代谢，这既代表了作者的主要经验，也是该科学实际应用的主要领域。讨论将主要基于药物代谢在药物研发应用中出现的广泛现象。
