Ji S G, Chai Y F, Wu Y T, Yin X P, Xiang Z B, Liang D S, Xu Z M, Li X
School of Pharmacy, Second Military Medical University, Shanghai, P. R. China.
Biomed Chromatogr. 1998 Nov-Dec;12(6):335-7. doi: 10.1002/(SICI)1099-0801(199811/12)12:6<335::AID-BMC758>3.0.CO;2-F.
A micellar electrokinetic capillary chromatographic method was set up for the quality control of rhubarb and its preparations. Anthraquinone derivatives were separated successfully within 10 min in the buffer solution of 50 mmol/L H3BO3-NaOH (pH 11) containing 25 mmol/L sodium deoxycholate. The established method, with a recovery of extraction of over 90%, has good linear relationship and reproducibility. The contents of anthraquinone derivatives in rhubarb and a tablet of Niu-huang-jie-du differed significantly, showing that the quality control of rhubarb and its preparations is necessary.
建立了胶束电动毛细管色谱法用于大黄及其制剂的质量控制。在含有25 mmol/L脱氧胆酸钠的50 mmol/L H3BO3-NaOH（pH 11）缓冲溶液中，蒽醌衍生物在10分钟内成功分离。所建立的方法提取回收率超过90%，具有良好的线性关系和重现性。大黄及牛黄解毒片中蒽醌衍生物的含量差异显著，表明对大黄及其制剂进行质量控制是必要的。
