Rao D, Jönsson E G, Paus S, Ganguli R, Nöthen M, Nimgaonkar V L
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA.
Psychiatr Genet. 1998 Winter;8(4):207-12. doi: 10.1097/00041444-199808040-00002.
A case control study was conducted among cases with schizophrenia (DSM IV criteria) and screened adult controls from three cohorts. Bi-allelic polymorphisms in the promoter region of the serotonin transporter gene (5-HTT) were examined in conjunction with those of the serotonin 5-HT2a receptor (HTR2). No significant association with 5-HTT was detected among US Caucasians (n = 207), African-Americans (n = 84) or Caucasians from Sweden (n = 221). However, survival analysis suggested an association with the age at onset among the Swedish cases. The association should be considered tentative as it was not evident in the smaller US samples. The following exploratory analyses among the US samples were also not significant: associations with subgroups of patients based on familiality or response to medications, or altered risk due to the joint effects of 5-HTT and HTR2 genotypes.
对符合精神分裂症（DSM-IV标准）的病例以及从三个队列中筛选出的成年对照进行了一项病例对照研究。对5-羟色胺转运体基因（5-HTT）启动子区域的双等位基因多态性以及5-羟色胺5-HT2a受体（HTR2）的双等位基因多态性进行了联合检测。在美国白人（n = 207）、非裔美国人（n = 84）或瑞典白人（n = 221）中，未检测到与5-HTT的显著关联。然而，生存分析表明，瑞典病例的发病年龄与之存在关联。鉴于在较小的美国样本中不明显，该关联应被视为初步结论。在美国样本中进行的以下探索性分析也不显著：基于家族性或药物反应的患者亚组关联，或5-HTT和HTR2基因型联合效应导致的风险改变。
