Geijer T, Frisch A, Persson M L, Wasserman D, Rockah R, Michaelovsky E, Apter A, Jönsson E G, Nöthen M M, Weizman A
National and Stockholm County Council Centre for Suicide Research and Prevention of Mental Ill-health, National Institute for Psychosocial Factors and Health, Sweden.
Psychiatr Genet. 2000 Mar;10(1):19-26. doi: 10.1097/00041444-200010010-00004.
Serotonergic neurotransmission has been implicated in suicidal behavior. Polymorphisms in the genes coding for tryptophan hydroxylase, serotonin receptor 2A and serotonin transporter were investigated in a sample of suicide attempters (n = 165) and healthy control subjects (n = 99). No significant differences were found for any of the investigated polymorphisms. Neither did any significant differences emerge in comparison with control subjects when the suicide attempters were grouped into different diagnostic categories: unipolar disorder (n = 45), adjustment disorder (n = 37), substance use disorder (n = 37) and personality disorder, cluster B (n = 36). The results suggest that alleles defined by the investigated polymorphisms do not represent a major determinant in suicide attempt. However, a highly significant (P = 0.001; odds ratio, 1.47; 99% confidence interval, 1.42-1.53) allelic association between tryptophan hydroxylase and suicide attempt is indicated after pooling our data with literature data. In light of previous data, a possible association between the tryptophan hydroxylase polymorphism and a phenotype that may become differently stratified within differently selected samples of suicide attempters is discussed.
血清素能神经传递与自杀行为有关。在一组自杀未遂者（n = 165）和健康对照者（n = 99）中，对编码色氨酸羟化酶、血清素受体2A和血清素转运体的基因多态性进行了研究。在所研究的任何多态性方面均未发现显著差异。当将自杀未遂者分为不同诊断类别时：单相情感障碍（n = 45）、适应障碍（n = 37）、物质使用障碍（n = 37）和B类人格障碍（n = 36），与对照者相比也未出现任何显著差异。结果表明，所研究的多态性所定义的等位基因并非自杀未遂的主要决定因素。然而，将我们的数据与文献数据汇总后，发现色氨酸羟化酶与自杀未遂之间存在高度显著的等位基因关联（P = 0.001；优势比，1.47；99%置信区间，1.42 - 1.53）。根据先前的数据，讨论了色氨酸羟化酶多态性与一种可能在不同选择的自杀未遂者样本中表现出不同分层的表型之间的可能关联。
