Morris N R, Efimov V P, Xiang X
Dept of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, USA.
Trends Cell Biol. 1998 Dec;8(12):467-70. doi: 10.1016/s0962-8924(98)01389-0.
During the past 20 years, biologists have become used to finding that proteins first identified in simple, genetically manipulable eukaryotic organisms are conserved in higher eukaryotes. This article draws attention to the similarity between NUDF protein, which is required for nuclear migration in the filamentous fungus Aspergillus nidulans, and a mammalian homologue, LIS1, whose malfunction causes lissencephaly, a neuronal migration disease. The authors suggest that there might be an underlying similarity of mechanism between nuclear migration in the fungus and neuronal migration in the brain.
在过去20年里，生物学家们已习惯于发现，最初在简单的、可进行基因操作的真核生物中鉴定出的蛋白质，在高等真核生物中是保守的。本文提请注意丝状真菌构巢曲霉中核迁移所需的NUDF蛋白与一种哺乳动物同源物LIS1之间的相似性，LIS1功能异常会导致无脑回畸形，这是一种神经元迁移疾病。作者们认为，真菌中的核迁移与大脑中的神经元迁移之间可能存在潜在的机制相似性。
