核定位。
Nuclear positioning.
机构信息
Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
出版信息
Cell. 2013 Mar 14;152(6):1376-89. doi: 10.1016/j.cell.2013.02.031.
Abstract
The nucleus is the largest organelle and is commonly depicted in the center of the cell. Yet during cell division, migration, and differentiation, it frequently moves to an asymmetric position aligned with cell function. We consider the toolbox of proteins that move and anchor the nucleus within the cell and how forces generated by the cytoskeleton are coupled to the nucleus to move it. The significance of proper nuclear positioning is underscored by numerous diseases resulting from genetic alterations in the toolbox proteins. Finally, we discuss how nuclear position may influence cellular organization and signaling pathways.
摘要
细胞核是最大的细胞器，通常位于细胞的中央。然而，在细胞分裂、迁移和分化过程中，它经常移动到与细胞功能相对应的不对称位置。我们考虑了使细胞核在细胞内移动和固定的蛋白质工具箱，以及细胞骨架产生的力如何与细胞核耦合以使其移动。由于工具箱蛋白的遗传改变导致许多疾病，因此正确的核定位的重要性得到了强调。最后，我们讨论了核定位如何影响细胞组织和信号通路。
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