Amortegui A J, Feinberg S S, Figallo E M
Biol Neonate. 1976;29(3-4):216-21. doi: 10.1159/000240866.
The effects of artificially induced intrauterine growth retardation on hematological values of the rat are manifest only temporarily in the red blood cell number, the amount of hemoglobin, and the 2,3-DPG. These three elements reached normal levels after the fifth day of postnatal life. We believe that this temporary effect may be the consequence of the short-term effect of hydroxyurea (the drug used to produce intrauterine growth retardation) upon DNA synthesis in the hematopoietic system. The animals compensate for the low red cell number and low hemoglobin by raising the levels of 2,3-DPG brought about by the temporary anoxia.
人工诱导的子宫内生长迟缓对大鼠血液学指标的影响仅在红细胞数量、血红蛋白量和2,3-二磷酸甘油酸（2,3-DPG）方面暂时显现。这三个指标在出生后第五天恢复到正常水平。我们认为，这种暂时的影响可能是由于羟基脲（用于产生子宫内生长迟缓的药物）对造血系统中DNA合成的短期作用所致。动物通过提高因暂时缺氧而产生的2,3-DPG水平来补偿红细胞数量和血红蛋白的不足。
