Willard M D, Berridge B, Braniecki A, Bouley D
Department of Small Animal Medicine, College of Veterinary Medicine, Texas A&M University, College Station 77843, USA.
J Am Vet Med Assoc. 1998 Dec 15;213(12):1775-9, 1753-4.
A Poodle referred for renal disease developed severe colonic disease characterized by total mucosal collapse and necrosis. The onset of colonic disease was temporally related to administration of antibiotics. On 3 occasions, bacterial culture of fecal samples yielded only Streptococcus pyogenes, Pseudomonas aeruginosa, and Candida albicans, suggesting that the colonic bacterial flora was severely disrupted. Findings, although not conclusive, were suggestive of antibiotic-associated colitis that ultimately proved fatal. Colonoscopy should be considered for dogs with unduly severe large-bowel diarrhea associated with antibiotic treatment and can be done with minimal restraint and bowel preparation, if necessary. Nonselective bacterial culture of fecal samples should be considered for dogs with unduly severe large-bowel diarrhea associated with antibiotic treatment.
一只因肾病转诊的贵宾犬出现了严重的结肠疾病，其特征为全层黏膜塌陷和坏死。结肠疾病的发作在时间上与抗生素的使用有关。有3次，粪便样本的细菌培养仅检出化脓性链球菌、铜绿假单胞菌和白色念珠菌，提示结肠菌群严重失调。尽管结果尚无定论，但提示为抗生素相关性结肠炎，最终导致死亡。对于因抗生素治疗而出现严重大肠腹泻的犬只，应考虑进行结肠镜检查，如有必要，可在最小程度的约束和肠道准备下进行。对于因抗生素治疗而出现严重大肠腹泻的犬只，应考虑进行粪便样本的非选择性细菌培养。
