Lai T Y, Wu Y W, Lin J G, Lin W C
Graduate Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan.
Am J Chin Med. 1998;26(3-4):343-51. doi: 10.1142/S0192415X98000385.
The effect of oral administration of a preparation of human urine (PHU) on the progression of acute liver injury was examined in rats intoxicated with carbon tetrachloride (CCl4) and alpha-naphthylisothiocyanate (ANIT) PHU protected the liver from CCl4-induced injury as judged by morphological and biochemical observations. In contrast, PHU aggravated ANIT-induced injury as judged also by morphological and biochemical observation. PHU prevented the increase in hepatic glutathione (GSH) and lipid peroxidation induced by CCl4. But PHU enhanced the increase in hepatic GSH caused by ANIT. These results indicate that the effect of PHU on hepatic GSH concentrations is through an indirect pathway. Clinical application of PHU on hepatitis should be explored further.
在四氯化碳（CCl4）和α-萘基异硫氰酸酯（ANIT）中毒的大鼠中，研究了口服人尿制剂（PHU）对急性肝损伤进展的影响。通过形态学和生化观察判断，PHU可保护肝脏免受CCl4诱导的损伤。相反，通过形态学和生化观察判断，PHU会加重ANIT诱导的损伤。PHU可阻止CCl4诱导的肝谷胱甘肽（GSH）增加和脂质过氧化。但PHU会增强ANIT引起的肝GSH增加。这些结果表明，PHU对肝GSH浓度的影响是通过间接途径。PHU在肝炎方面的临床应用应进一步探索。
