Shinkarenko V S
Biull Eksp Biol Med. 1976 Mar;81(3):360-3.
Intertesticular inoculation to rats of 1 ml of sarcoma suspension was accompanied by a rapid growth of the tumour at the site of inoculation and the spread of the tumour nodes to the omentum majus, porta hepatis, mesentery and the abdominal walls. After intraperitoneal inoculation the spread of the tumour nodes was similar. In these experiments animals died in 13-15 days. One month after the intratesticular inoculation of 0.2 ml of the tumour suspension-lung metastases were revealed in 74% of the animals with sarcoma-45 and in 90% of those with sarcoma-536. It was shown that tumour cells appeared in the blood stream already during the inoculation. However, laying of lung metastases occurred only after the formation of a primary tumour node at the site of transplantation. A conclusion was drawn that this system was a suitable experimental model for the study of the lung metastases development in rats.
给大鼠睾丸内接种1毫升肉瘤悬液后，接种部位的肿瘤迅速生长，肿瘤结节扩散至大网膜、肝门、肠系膜和腹壁。腹腔内接种后，肿瘤结节的扩散情况相似。在这些实验中，动物在13 - 15天内死亡。睾丸内接种0.2毫升肿瘤悬液1个月后，肉瘤-45的动物中有74%出现肺转移，肉瘤-536的动物中有90%出现肺转移。结果表明，肿瘤细胞在接种过程中就已进入血流。然而，肺转移灶仅在移植部位形成原发性肿瘤结节后才出现。得出的结论是，该系统是研究大鼠肺转移发生发展的合适实验模型。
