Grantyn' V A
Biull Eksp Biol Med. 1976 Jul;82(7):861-4.
The arcuate nucleus (AN) and the median eminence (ME) of the hypothalamus were investigated in young and ageing female rats. During the estral cycle (EC) the monoamine (MA) content, the monoaminoxidase (MAO), NADP and NAD-diaphorase activities were determined in the AN, and the MA content and the activity of alkaline phosphatase (AP) -- in the ME. In young rats in the proestrus-estrus there was an increase in the activity of the NADP and NAD-diaphorase and of the MA content, but a decrease of the MAO activity. This indicated an intensified function of the nucleus at these stages of the EC. Accumulation of the MA in the ME was noted in the diestrus, while in the proestrus their concentration sharply fell; on the other hand, the activity of the AP was considerably increased. In the ageing rats the dynamics of the indices under study during the EC were largely unchanged. However, the functional activity of the AN proved to increase, and in the ME and elevation of the MA concentration and disturbance of its release from the nerve terminals was seen.
对年轻和老龄雌性大鼠的下丘脑弓状核（AN）和正中隆起（ME）进行了研究。在发情周期（EC）期间，测定了AN中的单胺（MA）含量、单胺氧化酶（MAO）、NADP和NAD - 黄递酶活性，以及ME中的MA含量和碱性磷酸酶（AP）活性。在年轻大鼠的动情前期 - 发情期，NADP和NAD - 黄递酶活性以及MA含量增加，但MAO活性降低。这表明在EC的这些阶段该核的功能增强。在间情期注意到MA在ME中积累，而在动情前期其浓度急剧下降；另一方面，AP活性显著增加。在老龄大鼠中，EC期间所研究指标的动态变化基本未变。然而，AN的功能活性被证明增加，并且在ME中观察到MA浓度升高及其从神经末梢释放受到干扰。
